Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.
نویسندگان
چکیده
Treatment of prostate cancer cell lines expressing bcl-2 with taxol induces bcl-2 phosphorylation and programmed cell death, whereas treatment of bcl-2-negative prostate cancer cells with taxol does not induce apoptosis. bcl-2 phosphorylation seems to inhibit its binding to bax since less bax was observed in immunocomplex with bcl-2 in taxol-treated cancer cells. These findings support the use of the anticancer drug taxol for the treatment of bcl-2-positive prostate cancers and other bcl-2-positive malignancies, such as follicular lymphoma.
منابع مشابه
Taxol Induces bcl-2 Phosphorylation and Death of Prostate Cancer Cells1
Treatment of prostate cancer cell lines expressing bcl-2 with taxol induces bcl-2 phosphorylation and programmed cell death, whereas treat ment of ¿>c/-2-negativeprostate cancer cells with taxol does not induce apoptosis. bcl-2 phosphorylation seems to inhibit its binding to box since less box was observed in immunocomplex with bcl-2 in taxol-treated cancer cells. These findings support the us...
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عنوان ژورنال:
- Cancer research
دوره 56 6 شماره
صفحات -
تاریخ انتشار 1996